Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PGK1 | P00558 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984792 | 0.82 | MAPT (0.47) | KMT2APGK1KDM4EALDH1A1HPGD | |
| SCHEMBL5860169 | 0.82 | KMT2A (0.51) | KMT2APGK1KDM4EALDH1A1HPGD | |
| SCHEMBL9319008 | 0.74 | TNF (0.50) | KMT2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6220430 | 0.73 | PGK1 (0.44) | KMT2APGK1KDM4EALDH1A1HPGD | |
| SCHEMBL5860061 | 0.71 | PGK1 (0.46) | KMT2APGK1MAPTGAARIOK3 | |
| SCHEMBL14492309 | 0.69 | MAPT (0.49) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL31721290 | 0.67 | KDM4E (0.43) | KMT2AKDM4EALDH1A1MAPTGAA | |
| SCHEMBL5860177 | 0.66 | MAPT (0.44) | KMT2APGK1KDM4EALDH1A1HPGD | |
| SCHEMBL7698253 | 0.66 | KDM4E (0.46) | KMT2AKDM4EALDH1A1MAPTGAA | |
| SCHEMBL1424815 | 0.66 | GABRP (0.48) | KDM4EALDH1A1HSD17B10MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313135-B1 | FOR THERAPY OF LEUKEMIA, COLON CANCER OR LUNG CANCER IN WARM-BLOODED ANIMALS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-11-06 | — | — | US | disclosed |
| US-5981542-A | TOPOISOMERASE INHIBITORS; ANTITUMORAL DRUGS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-11-09 | — | — | US | disclosed |