Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 6/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.39 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972876 | 1.00 | ALOX5 (0.47) | ALOX5BRD4KDM1AMAOBKCNH2 | |
| SCHEMBL7973297 | 1.00 | ALOX5 (0.47) | ALOX5BRD4KDM1AMAOBKCNH2 | |
| SCHEMBL7976148 | 0.83 | ALOX5 (0.47) | ALOX5HTR2CHTR2BMAPTKMT2A | |
| SCHEMBL7972931 | 0.83 | ALOX5 (0.47) | ALOX5MAOBMAOAHTR2CHTR2B | |
| SCHEMBL7973200 | 0.83 | ALOX5 (0.47) | ALOX5HTR2CHTR2BMAPTKMT2A | |
| SCHEMBL7969766 | 0.83 | ALOX5 (0.47) | ALOX5MAOBMAOAHTR2CHTR2B | |
| SCHEMBL7972814 | 0.83 | ALOX5 (0.64) | ALOX5KDM1AKCNH2HTR2CHTR2B | |
| SCHEMBL7969764 | 0.83 | ALOX5 (0.47) | ALOX5MAOBMAOAHTR2CHTR2B | |
| SCHEMBL7973196 | 0.83 | ALOX5 (0.47) | ALOX5HTR2CHTR2BMAPTKMT2A | |
| SCHEMBL7959777 | 0.83 | ALOX5 (0.64) | ALOX5KDM1AKCNH2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |