Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972903 | 1.00 | SIGMAR1 (0.62) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL7972898 | 1.00 | SIGMAR1 (0.62) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL6742274 | 0.83 | MAPT (0.66) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL6742277 | 0.83 | MAPT (0.66) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL6741206 | 0.82 | MAPT (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL27979641 | 0.82 | MAPT (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL4048121 | 0.82 | MAPT (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL3327949 | 0.81 | SIGMAR1 (0.60) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL7983385 | 0.79 | SIGMAR1 (0.55) | SIGMAR1 | |
| SCHEMBL7983388 | 0.79 | SIGMAR1 (0.55) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |