Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983385 | 1.00 | SIGMAR1 (0.55) | SIGMAR1TDP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7972896 | 0.79 | SIGMAR1 (0.62) | SIGMAR1 | |
| SCHEMBL7972898 | 0.79 | SIGMAR1 (0.62) | SIGMAR1 | |
| SCHEMBL7972903 | 0.79 | SIGMAR1 (0.62) | SIGMAR1 | |
| SCHEMBL7986506 | 0.78 | KDM4E (0.56) | TDP1KDM4EALDH1A1HTR1AACHE | |
| SCHEMBL7986503 | 0.78 | KDM4E (0.56) | TDP1KDM4EALDH1A1HTR1AACHE | |
| SCHEMBL6742274 | 0.78 | MAPT (0.66) | SIGMAR1ACHE | |
| SCHEMBL6742277 | 0.78 | MAPT (0.66) | SIGMAR1ACHE | |
| SCHEMBL6741206 | 0.76 | MAPT (0.68) | SIGMAR1ACHE | |
| SCHEMBL4048121 | 0.76 | MAPT (0.68) | SIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |