Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3891985 | 0.87 | TSHR (0.54) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL176214 | 0.78 | ALOX15 (0.55) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL30746861 | 0.78 | ALOX15 (0.55) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL3464071 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL1280719 | 0.77 | ALOX15 (0.53) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL11245928 | 0.77 | TSHR (0.51) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL7969480 | 0.77 | TSHR (0.55) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 | |
| Hydrochloric Acid SCHEMBL31124708 | 0.77 | ALOX15 (0.53) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL1178753 | 0.77 | TSHR (0.51) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 | |
| Hydrochloric Acid SCHEMBL11258002 | 0.75 | TSHR (0.50) | TSHRNPC1RAB9ASMN1; SMN2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | disclosed |