Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7972901 | 0.87 | TSHR (0.48) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| SCHEMBL176214 | 0.86 | ALOX15 (0.55) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| SCHEMBL30746861 | 0.86 | ALOX15 (0.55) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| Hydrochloric Acid SCHEMBL31124708 | 0.84 | ALOX15 (0.53) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| SCHEMBL11245928 | 0.84 | TSHR (0.51) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| Hydrochloric Acid SCHEMBL1280719 | 0.84 | ALOX15 (0.53) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| SCHEMBL7969480 | 0.84 | TSHR (0.55) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| SCHEMBL1178753 | 0.84 | TSHR (0.51) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| Hydrochloric Acid SCHEMBL11258002 | 0.82 | TSHR (0.50) | TSHRNPC1SMN1; SMN2RAB9APSMB5 | |
| SCHEMBL7583697 | 0.81 | TSHR (0.56) | TSHRNPC1SMN1; SMN2RAB9APSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660464-B1 | CASPASE INHIBITORS CONTAINING ISOXAZOLINE RING | LG LIFE SCIENCES LTD (KR) | 2015-02-25 | — | — | EP | disclosed |
| US-7557133-B2 | Caspase inhibitors containing isoxazoline ring | LG LIFE SCIENCES LTD. (KR) | 2009-07-07 | — | — | US | disclosed |
| EP-1660464-A4 | CASPASE INHIBITORS CONTAINING ISOXAZOLINE RING | LG LIFE SCIENCES LTD (KR) | 2008-11-26 | — | — | EP | disclosed |
| US-20060223848-A1 | Caspase inhibitors containing isoxazoline ring | LG CHEM, LTD. (KR) | 2006-10-05 | — | — | US | disclosed |
| EP-1660464-A1 | CASPASE INHIBITORS CONTAINING ISOXAZOLINE RING | LG Life Sciences Ltd. (KR) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021516-A1 | CASPASE INHIBITORS CONTAINING ISOXAZOLINE RING | LG LIFE SCIENCES LTD. (KR) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223848-A1 | Caspase inhibitors containing isoxazoline ring | CASP1, CASP7, CASP2 | TSHR 4742/4885NPC1 1937/4885SMN1; SMN2 2866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.