Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.51 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970872 | 0.90 | ALOX5 (0.47) | ALOX5SLC9A1TP53LMNAPOLB | |
| SCHEMBL7970869 | 0.90 | ALOX5 (0.47) | ALOX5SLC9A1TP53LMNAPOLB | |
| SCHEMBL7959765 | 0.75 | ALOX5 (0.53) | ALOX5SLC9A1DPP4DPP8DPP9 | |
| SCHEMBL7971261 | 0.75 | ALOX5 (0.47) | ALOX5SLC9A1TP53POLBALDH1A1 | |
| SCHEMBL7969804 | 0.75 | ALOX5 (0.62) | ALOX5SLC9A1 | |
| SCHEMBL7971120 | 0.75 | ALOX5 (0.53) | ALOX5SLC9A1DPP4DPP8DPP9 | |
| SCHEMBL7971258 | 0.75 | ALOX5 (0.47) | ALOX5SLC9A1TP53POLBALDH1A1 | |
| SCHEMBL7959762 | 0.75 | ALOX5 (0.53) | ALOX5SLC9A1DPP4DPP8DPP9 | |
| SCHEMBL7971122 | 0.75 | ALOX5 (0.53) | ALOX5SLC9A1DPP4DPP8DPP9 | |
| SCHEMBL7969802 | 0.75 | ALOX5 (0.62) | ALOX5SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |