Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13573073 | 0.87 | BCHE (0.59) | KMT2A | |
| SCHEMBL7392116 | 0.87 | SIGMAR1 (0.55) | CHRNB2CHRNA4SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL7385234 | 0.84 | SIGMAR1 (0.52) | CHRNB2CHRNA4SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL7392114 | 0.84 | LTA4H (0.58) | SIGMAR1LTA4HEPHX2KDM4EKMT2A | |
| SCHEMBL7385230 | 0.84 | SIGMAR1 (0.55) | SIGMAR1LTA4HEPHX2 | |
| SCHEMBL7392112 | 0.84 | LTA4H (0.58) | SIGMAR1LTA4HEPHX2KDM4EKMT2A | |
| SCHEMBL7385226 | 0.84 | SIGMAR1 (0.55) | SIGMAR1LTA4HEPHX2 | |
| SCHEMBL1707811 | 0.83 | SIGMAR1 (0.56) | CHRNB2CHRNA4SIGMAR1CHRNB4CHRNA3 | |
| SCHEMBL7388024 | 0.81 | SIGMAR1 (0.48) | SIGMAR1 | |
| SCHEMBL24833934 | 0.81 | SIGMAR1 (0.57) | SIGMAR1LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |