Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10140005 | 0.87 | PTGDR2 (0.33) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7960749 | 0.85 | HDAC3 (0.43) | GRK6HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL7973068 | 0.81 | CHEK2 (0.39) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7970984 | 0.80 | SYK (0.32) | — | |
| SCHEMBL7973410 | 0.74 | PTGDR2 (0.36) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL20307807 | 0.73 | KMT2A (0.34) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL10140040 | 0.73 | CHEK2 (0.34) | — | |
| SCHEMBL7975823 | 0.72 | HDAC3 (0.43) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL10140128 | 0.71 | F10 (0.34) | HDAC1HDAC6KLKB1PTGDR2BRPF1 | |
| SCHEMBL7972878 | 0.71 | HPSE (0.38) | KDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |