Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.40 |
| ▸ | AURKA | O14965 | 10/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.39 |
| ▸ | CDK1 | P06493 | 8/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.39 |
| ▸ | CDK2 | P24941 | 7/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | STK25 | O00506 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975823 | 0.87 | HDAC3 (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7973086 | 0.85 | GRK6 (0.33) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7973068 | 0.81 | CHEK2 (0.39) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7970984 | 0.80 | SYK (0.32) | SYK | |
| SCHEMBL7980064 | 0.75 | GSK3B (0.49) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7961555 | 0.73 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7975606 | 0.73 | BRD4 (0.37) | — | |
| SCHEMBL10140040 | 0.73 | CHEK2 (0.34) | — | |
| SCHEMBL10140005 | 0.72 | PTGDR2 (0.33) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL10140130 | 0.72 | HDAC3 (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |