Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975606 | 0.85 | BRD4 (0.37) | CHEK2BRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7960176 | 0.84 | BRD4 (0.36) | CHEK2BRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7975112 | 0.80 | F9 (0.47) | HPSECHEK2BRD4ALDH1A1MAPT | |
| SCHEMBL7973068 | 0.79 | CHEK2 (0.39) | HPSECHEK2RHEBCDK4CCNA2 | |
| SCHEMBL20307729 | 0.76 | F9 (0.40) | HPSECHEK2CDK4CCNA2CCND1 | |
| SCHEMBL7969308 | 0.76 | TSPO (0.37) | CHEK2EGFRBRD4KDR | |
| SCHEMBL7980011 | 0.73 | CHEK2 (0.38) | HPSECHEK2EGFRBRD4ALDH1A1 | |
| SCHEMBL7970984 | 0.72 | SYK (0.32) | — | |
| SCHEMBL7977818 | 0.72 | F9 (0.48) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL7960749 | 0.71 | HDAC3 (0.43) | CDK4CDK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |