Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.33 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10140006 | 0.85 | CHEK2 (0.38) | CHEK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL7970984 | 0.82 | SYK (0.32) | SYKITK | |
| SCHEMBL7960749 | 0.81 | HDAC3 (0.43) | CHEK1CDK4CDK2FLT3HDAC6 | |
| SCHEMBL7973086 | 0.81 | GRK6 (0.33) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL7972878 | 0.79 | HPSE (0.38) | CHEK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL10172564 | 0.77 | MAPT (0.37) | HDAC6HDAC1HPSE | |
| SCHEMBL7960714 | 0.76 | CHEK2 (0.39) | CHEK2 | |
| SCHEMBL10140040 | 0.74 | CHEK2 (0.34) | CHEK2 | |
| SCHEMBL7969308 | 0.73 | TSPO (0.37) | CHEK2SYKITK | |
| SCHEMBL7975606 | 0.72 | BRD4 (0.37) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |