SCHEMBL7973146

SCHEMBL7973146

CC(C)CCC(=O)NCCCc1c[nH]cn1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.42
PKM P14618 1/20 0.42
HPGD P15428 3/20 0.40
HTT P42858 2/20 0.39
GLA P06280 1/20 0.39
MAPT P10636 1/20 0.39
HRH3 Q9Y5N1 1/20 0.38
ALDH1A1 P00352 3/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
PSMB5 P28074 1/20 0.36
CNR1 P21554 2/20 0.36
NAMPT P43490 1/20 0.36
CNR2 P34972 1/20 0.36
KMT2A Q03164 1/20 0.35
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7961176 0.83 FAAH (0.50) HPGDMAPTCNR1KMT2AHSD17B10
SCHEMBL7977295 0.82 FAAH (0.52) HPGDMAPTKMT2AHSD17B10
SCHEMBL7971173 0.82 FAAH (0.52) HPGDMAPTKMT2AHSD17B10
SCHEMBL27056225 0.81 HRH3 (0.42) LMNAPKMHPGDHTTHRH3
SCHEMBL18381452 0.81 LMNA (0.49) LMNAMAPTSMN1; SMN2L3MBTL1KMT2A
SCHEMBL19059571 0.79 CA1 (0.36) LMNAL3MBTL1
SCHEMBL17473832 0.79 HDAC3 (0.41) LMNAMAPTKMT2A
SCHEMBL17473829 0.79 HDAC3 (0.42) LMNAMAPTSMN1; SMN2KMT2A
SCHEMBL17473827 0.78 CYP3A4 (0.41) LMNAHPGDL3MBTL1KMT2A
SCHEMBL7974337 0.78 L3MBTL1 (0.58) LMNAHPGDL3MBTL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE37303-E1 Imidazole compounds and their therapeutic applications INSTITUT NATIONAL DEL LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 2001-07-31 US claimed
US-5708171-A HISTAMINE H3-RECEPTOR ANTAGONIST INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 1998-01-13 US claimed
EP-0597088-A1 NOVEL IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATIONS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1994-05-18 EP claimed
WO-1993014070-A2 NOVEL IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATIONS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 1993-07-22 WO claimed
US-RE37303-E1 Imidazole compounds and their therapeutic applications INSTITUT NATIONAL DEL LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 2001-07-31 US disclosed
US-5708171-A HISTAMINE H3-RECEPTOR ANTAGONIST INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 1998-01-13 US disclosed
US-5559113-A ANTAGONISTS TO HISTAMINE H3 RECEPTORS, SEDATIVES, ANTICONVULSANTS, ANTIULCER AGENTS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 1996-09-24 US disclosed
EP-0597088-A1 NOVEL IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATIONS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1994-05-18 EP disclosed
WO-1993014070-A2 NOVEL IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATIONS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 1993-07-22 WO disclosed