Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948937 | 0.85 | EGFR (0.40) | RPS6KB1LMNAALDH1A1TSHRCYP1A2 | |
| SCHEMBL8132510 | 0.74 | LMNA (0.53) | RPS6KB1LMNASMN1; SMN2PIK3CDPIK3R1 | |
| SCHEMBL30092928 | 0.73 | PDE4A (0.44) | RPS6KB1ALDH1A1PDE5AKDM4ETSHR | |
| SCHEMBL19145083 | 0.72 | ALDH1A1 (0.47) | RPS6KB1LMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12889093 | 0.70 | ALDH1A1 (0.54) | LMNASMN1; SMN2ALDH1A1PDE5AKDM4E | |
| SCHEMBL20394335 | 0.70 | LMNA (0.48) | RPS6KB1LMNASMN1; SMN2PIK3CDPIK3R1 | |
| SCHEMBL20406386 | 0.70 | ALDH1A1 (0.45) | LMNASMN1; SMN2ALDH1A1KDM4ETSHR | |
| SCHEMBL27855245 | 0.70 | TSHR (0.48) | LMNASMN1; SMN2ALDH1A1KDM4ETSHR | |
| SCHEMBL8127484 | 0.69 | EGFR (0.50) | RPS6KB1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL30775396 | 0.69 | CSF1R (0.49) | RPS6KB1LMNASMN1; SMN2PIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | claimed |