Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5862678 | 0.87 | GABRA1 (0.41) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL6222498 | 0.87 | DHODH (0.38) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL5862670 | 0.80 | TNF (0.39) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL7986686 | 0.78 | MAPT (0.41) | ALDH1A1GAAL3MBTL1LMNAMEN1 | |
| SCHEMBL12803333 | 0.77 | NR1H2 (0.44) | ALDH1A1GAALMNAMEN1MAPT | |
| SCHEMBL3092788 | 0.77 | NR1H2 (0.44) | ALDH1A1GAALMNAMEN1MAPT | |
| SCHEMBL6224039 | 0.76 | DHODH (0.37) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL5859825 | 0.74 | LMNA (0.50) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL4651297 | 0.71 | DPP4 (0.52) | ALDH1A1GAAL3MBTL1MEN1MAPT | |
| SCHEMBL22256 | 0.69 | TSHR (0.52) | ALDH1A1GAAL3MBTL1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313135-B1 | FOR THERAPY OF LEUKEMIA, COLON CANCER OR LUNG CANCER IN WARM-BLOODED ANIMALS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-11-06 | — | — | US | disclosed |
| US-5981542-A | TOPOISOMERASE INHIBITORS; ANTITUMORAL DRUGS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-11-09 | — | — | US | disclosed |