Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
| ▸ | GLP1R | P43220 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5860177 | 0.90 | MAPT (0.44) | MAPTGAATHRBALDH1A1KDM4E | |
| SCHEMBL6219800 | 0.86 | MTNR1A (0.38) | MAPTALDH1A1LMNAMTNR1AMTNR1B | |
| SCHEMBL5862670 | 0.79 | TNF (0.39) | MAPTGAAALDH1A1KDM4ETNF | |
| SCHEMBL7973906 | 0.78 | GABRA1 (0.42) | MAPTGAAALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6220451 | 0.77 | PGK1 (0.41) | MAPTALDH1A1SMN1; SMN2LMNAMTNR1A | |
| SCHEMBL14492309 | 0.77 | MAPT (0.49) | MAPTGAATHRBALDH1A1KDM4E | |
| SCHEMBL5859933 | 0.77 | KDM4E (0.43) | MAPTTHRBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7984792 | 0.77 | MAPT (0.47) | MAPTGAATHRBALDH1A1KDM4E | |
| SCHEMBL5860143 | 0.75 | LMNA (0.49) | MAPTGAAALDH1A1KDM4ENPSR1 | |
| SCHEMBL5860087 | 0.74 | ALDH1A1 (0.40) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313135-B1 | FOR THERAPY OF LEUKEMIA, COLON CANCER OR LUNG CANCER IN WARM-BLOODED ANIMALS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-11-06 | — | — | US | disclosed |
| US-5981542-A | TOPOISOMERASE INHIBITORS; ANTITUMORAL DRUGS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-11-09 | — | — | US | disclosed |