Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655376 | 0.87 | HSD17B10 (0.43) | P2RX7HSD17B10PIM1MAPK14BCHE | |
| SCHEMBL7987232 | 0.80 | KMT2A (0.41) | HSD17B10PIM1DPP4PRKD2KDM4E | |
| SCHEMBL7991356 | 0.76 | GABRG2 (0.57) | — | |
| SCHEMBL7984270 | 0.75 | BCHE (0.39) | HSD17B10BCHEKDM4EALDH1A1POLB | |
| SCHEMBL6773500 | 0.69 | MAPK14 (0.39) | P2RX7HSD17B10PIM1MAPK14HSD11B1 | |
| SCHEMBL7987387 | 0.66 | NPC1 (0.40) | BCHEACHEBACE1EGFRKDM4E | |
| SCHEMBL7987392 | 0.66 | NPC1 (0.40) | BCHEACHEBACE1EGFRKDM4E | |
| SCHEMBL6775681 | 0.66 | HSD11B1 (0.43) | HSD11B1POLB | |
| SCHEMBL6775795 | 0.63 | DCTPP1 (0.45) | HSD11B1ALDH1A1POLB | |
| SCHEMBL7972521 | 0.63 | BCHE (0.42) | HSD17B10BCHEKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319924-B1 | FOR THERAPY OF DELETERIOUS MENTAL STATES | MERCK SHARP & DOHME LTD. (GB) | 2001-11-20 | — | — | US | disclosed |