Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812410 | 0.89 | TDP1 (0.54) | TDP1APPHCAR2ESR1ESR2 | |
| SCHEMBL451184 | 0.86 | TDP1 (0.68) | TDP1APPHCAR2ESR1ESR2 | |
| SCHEMBL528359 | 0.83 | ALDH1A1 (0.59) | TDP1HCAR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL451185 | 0.82 | TDP1 (0.63) | TDP1APPHCAR2ESR1ESR2 | |
| SCHEMBL15122553 | 0.82 | MEN1 (0.49) | TDP1APPHCAR2ALOX5NPC1 | |
| SCHEMBL14601342 | 0.82 | HSD17B10 (0.43) | TDP1ALDH1A1TP53TSHRHIF1A | |
| SCHEMBL10873748 | 0.81 | ALDH1A1 (0.58) | TDP1HCAR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3345622 | 0.79 | TDP1 (0.59) | TDP1APPHCAR2ESR1ESR2 | |
| SCHEMBL8881369 | 0.79 | TDP1 (0.59) | TDP1APPHCAR2ESR1ESR2 | |
| SCHEMBL13560198 | 0.79 | TDP1 (0.59) | TDP1APPHCAR2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268511-B1 | USED FOR PRODUCING COPOLYMER WITH ACRYLIC ESTER COMONOMERS; COPOLYMERS ARE USED FOR FOLDABLE INTRAOCULAR LENSES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-07-31 | — | — | US | disclosed |
| EP-0987247-A1 | ITACONATE DERIVATIVES USED FOR A COMPONENT OF A POLYMER | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2000-03-22 | — | — | EP | disclosed |