Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 9/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979349 | 0.90 | HCAR3 (0.44) | HCAR3RXRAMAPTGBA1PPARG | |
| SCHEMBL7803954 | 0.90 | MEN1 (0.44) | HCAR3MEN1KMT2AHTTMAPK1 | |
| SCHEMBL7963017 | 0.89 | HCAR3 (0.45) | HCAR3RXRAGBA1PPARG | |
| SCHEMBL7963014 | 0.89 | HCAR3 (0.45) | HCAR3RXRAGBA1PPARG | |
| SCHEMBL7976850 | 0.89 | RXRA (0.54) | HCAR3RXRAGBA1PPARG | |
| SCHEMBL7672615 | 0.87 | HCAR3 (0.51) | HCAR3RXRAMAPTSMN1; SMN2GBA1 | |
| SCHEMBL7810643 | 0.86 | RXRA (0.53) | HCAR3RXRAGBA1PPARG | |
| SCHEMBL7973303 | 0.85 | HCAR3 (0.43) | HCAR3RXRAGBA1PPARG | |
| SCHEMBL27430043 | 0.85 | KMT2A (0.43) | MEN1KMT2AHTTMAPK1POLB | |
| SCHEMBL7974544 | 0.85 | HCAR3 (0.45) | HCAR3RXRAGBA1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313148-B1 | FOR THERAPY OF PAIN PAIN ASSOCIATED WITH JOINT CONDITIONS SUCH AS RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS, POSTOPERATIVE PAIN, POST-PARTUM PAIN, THE PAIN ASSOCIATED WITH DENTAL CONDITIONS SUCH AS DENTAL CARIES AND GINGIVITIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | claimed |