Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623585 | 1.00 | CHRM4 (0.46) | CHRM4MMP2MMP9ADAM17OPRM1 | |
| SCHEMBL8261399 | 0.80 | CHRM4 (0.47) | CHRM4MMP2MMP9ADAM17OPRM1 | |
| SCHEMBL4602613 | 0.79 | OPRL1 (0.67) | CHRM4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4602609 | 0.79 | OPRL1 (0.67) | CHRM4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL2295519 | 0.74 | CHRM4 (0.47) | CHRM4HRH3BCHEALOX5FDFT1 | |
| SCHEMBL2295867 | 0.74 | CHRM4 (0.47) | CHRM4HRH3BCHEALOX5FDFT1 | |
| SCHEMBL2297996 | 0.74 | CHRM4 (0.47) | CHRM4HRH3BCHEALOX5FDFT1 | |
| SCHEMBL2295049 | 0.74 | CHRM4 (0.47) | CHRM4HRH3BCHEALOX5FDFT1 | |
| SCHEMBL4602232 | 0.72 | CHRM4 (0.54) | CHRM4HRH3ALOX5FDFT1MAPK1 | |
| SCHEMBL4601018 | 0.72 | CHRM4 (0.54) | CHRM4HRH3ALOX5FDFT1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268499-B1 | USEFUL AS RENIN INHIBITORS | HOFFMAN-LA ROCHE INC. | 2001-07-31 | — | — | US | disclosed |