Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11708352 | 0.98 | L3MBTL1 (0.59) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| SCHEMBL1249120 | 0.92 | HTR1B (0.56) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL14830577 | 0.90 | KDM4E (0.57) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| SCHEMBL1032880 | 0.86 | KDM4E (0.68) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| SCHEMBL7968991 | 0.85 | TDP1 (0.54) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL6492504 | 0.84 | KDM4E (0.72) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| SCHEMBL9808263 | 0.81 | L3MBTL1 (0.68) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| SCHEMBL11662071 | 0.81 | L3MBTL1 (0.62) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| SCHEMBL8748237 | 0.81 | L3MBTL1 (0.57) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 | |
| SCHEMBL8956162 | 0.81 | L3MBTL1 (0.57) | L3MBTL1MAPTTDP1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8604065-B2 | Pyridyl cyanoguanidine derivatives | Zhang, Hesheng (CN) | 2013-12-10 | — | — | US | disclosed |
| US-20120309797-A1 | PYRIDYL CYANOGUANIDINE DERIVATIVES | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) | 2012-12-06 | — | — | US | disclosed |
| US-6303641-B1 | FOR THERAPY AND PROPHYLAXIS OF DISEASES CHARACTERIZED BY ABNORMAL CELL DIFFERENTIATION AND/OR CELL PROLIFERATION SUCH AS PSORIASIS AND CANCER | LEO PHARMACEUTICALS PRODUCTS LTD. (DK) | 2001-10-16 | — | — | US | disclosed |
| EP-0984940-A1 | CYANOAMIDINES AS CELL PROLIFERATION INHIBITORS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054147-A1 | CYANOAMIDINES AS CELL PROLIFERATION INHIBITORS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-12-03 | — | — | WO | disclosed |
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309797-A1 | PYRIDYL CYANOGUANIDINE DERIVATIVES | PNPO, XDH, PDXK | L3MBTL1 2477/4885MAPT 4716/4885TDP1 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.