Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11355262 | 0.89 | MAPT (0.63) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL8886349 | 0.88 | MAPT (0.59) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL4903737 | 0.87 | NPC1 (0.57) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL5579639 | 0.85 | CTSV (0.55) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL4892299 | 0.85 | LMNA (0.51) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL8886856 | 0.85 | KMT2A (0.55) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL2212705 | 0.85 | AKR1C3 (0.68) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL31218599 | 0.84 | CHRNB2 (0.53) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL5838060 | 0.83 | MAPK1 (0.62) | RAB9AKMT2ANPC1MEN1MAPT | |
| SCHEMBL8884987 | 0.83 | MAPT (0.52) | RAB9AKMT2ANPC1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |