Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12212987 | 0.81 | TRIM24 (0.36) | — | |
| SCHEMBL12208421 | 0.81 | MEN1 (0.42) | KDM1ASLC6A2SLC6A3HTR2C | |
| SCHEMBL2360390 | 0.79 | KDM1A (0.52) | KDM1AHRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6167456 | 0.77 | KDM1A (0.39) | KDM1ASLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL20646429 | 0.74 | SLC6A2 (0.51) | KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13594763 | 0.74 | — | — | |
| SCHEMBL1645757 | 0.71 | KDM1A (0.63) | KDM1AHRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7898071 | 0.71 | KDM1A (0.63) | KDM1AHRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3717972 | 0.71 | KDM1A (0.63) | KDM1AHRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8326083 | 0.71 | KDM1A (0.47) | KDM1AHRH3SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |