Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975876 | 0.77 | KDM1A (0.42) | KDM1ASLC6A3SLC6A4SLC6A2HTR2A | |
| SCHEMBL2360390 | 0.74 | KDM1A (0.52) | KDM1ASLC6A3SLC6A4SLC6A2HTR2A | |
| SCHEMBL14920864 | 0.71 | SLC9A1 (0.40) | KDM1ASLC6A3SLC6A4FPR2SLC9A1 | |
| SCHEMBL27997309 | 0.71 | TACR1 (0.40) | KDM1ASLC6A3SLC6A4SLC6A2HTR2A | |
| SCHEMBL26244344 | 0.69 | KDM1A (0.46) | KDM1ASLC6A3SLC6A4SLC6A2HTR2A | |
| SCHEMBL14934623 | 0.69 | SLC6A4 (0.45) | KDM1ASLC6A3SLC6A4SLC6A2HTR2A | |
| SCHEMBL16141291 | 0.69 | SLC6A4 (0.45) | KDM1ASLC6A3SLC6A4SLC6A2HTR2A | |
| SCHEMBL27936036 | 0.68 | TSHR (0.39) | KDM1ASLC6A3SLC6A2HTR2AHTR2C | |
| SCHEMBL20408742 | 0.67 | KDM1A (0.47) | KDM1ASLC6A3SLC6A4SLC6A2HTR2A | |
| SCHEMBL14934470 | 0.67 | SLC6A3 (0.50) | SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1527062-A1 | TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004009573-A1 | TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 2004-01-29 | — | — | WO | disclosed |