Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6ST | P40189 | 5/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 3/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.32 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986429 | 0.98 | IL6ST (0.35) | IL6STSTAT3EDNRAIDH1APLNR | |
| SCHEMBL7986613 | 0.95 | EDNRA (0.34) | IL6STSTAT3EDNRAIDH1SCD5 | |
| SCHEMBL7994175 | 0.92 | EDNRA (0.35) | IL6STSTAT3EDNRAIDH1SCD5 | |
| SCHEMBL7994192 | 0.85 | EDNRA (0.41) | EDNRAAPLNRITGB3ITGAVITGA2B | |
| SCHEMBL7986434 | 0.82 | EDNRA (0.41) | EDNRAAPLNRITGB3ITGAVITGA2B | |
| SCHEMBL8810101 | 0.80 | IL6ST (0.36) | IL6STSTAT3EDNRAIDH1ITGB3 | |
| SCHEMBL7994654 | 0.80 | EDNRA (0.44) | EDNRAMAPT | |
| SCHEMBL7986399 | 0.79 | EDNRA (0.42) | EDNRAITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL8811832 | 0.78 | IL6ST (0.35) | IL6STSTAT3EDNRAIDH1APLNR | |
| SCHEMBL7989782 | 0.77 | EDNRA (0.44) | EDNRAAPLNRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |