Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | IL6ST | P40189 | 5/20 | 0.33 |
| ▸ | OGA | O60502 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986613 | 0.94 | EDNRA (0.34) | EDNRAIDH1SCD5IL6STHPGD | |
| SCHEMBL7986429 | 0.93 | IL6ST (0.35) | EDNRAIDH1SCD5IL6STSTAT3 | |
| SCHEMBL7975894 | 0.92 | IL6ST (0.36) | EDNRAIDH1SCD5IL6STSTAT3 | |
| SCHEMBL7987573 | 0.83 | EDNRA (0.44) | EDNRASCD5OGAHPGDKDM4E | |
| SCHEMBL13928771 | 0.79 | IL6ST (0.40) | EDNRAIDH1IL6STHPGDKDM4E | |
| SCHEMBL13916990 | 0.79 | IL6ST (0.40) | EDNRAIDH1IL6STHPGDKDM4E | |
| SCHEMBL8810786 | 0.79 | EDNRA (0.35) | EDNRAIDH1IL6STOGASTAT3 | |
| SCHEMBL7987522 | 0.78 | EDNRA (0.47) | EDNRAHPGDNPC1RAB9AMAPT | |
| SCHEMBL7986399 | 0.77 | EDNRA (0.42) | EDNRASCD5KDM4ECYP26A1MAPT | |
| SCHEMBL8810732 | 0.76 | EDNRA (0.34) | EDNRAIDH1IL6STOGASTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |