Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8817317 | 1.00 | SGMS2 (0.48) | SGMS2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL7990565 | 0.89 | SGMS2 (0.50) | SGMS2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL7989643 | 0.89 | SGMS2 (0.50) | SGMS2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL7990312 | 0.80 | ITGB2 (0.49) | — | |
| SCHEMBL7975824 | 0.77 | SGMS2 (0.52) | SGMS2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL7990641 | 0.77 | SGMS2 (0.52) | SGMS2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL7987708 | 0.77 | SGMS2 (0.52) | SGMS2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL7993776 | 0.77 | ERAP2 (0.52) | — | |
| SCHEMBL7990821 | 0.73 | TDP1 (0.47) | SGMS2MEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL7975922 | 0.73 | SGMS2 (0.46) | SGMS2PTGER1PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |