Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989643 | 1.00 | SGMS2 (0.50) | SGMS2ALDH1A1MEN1KMT2APTGER1 | |
| SCHEMBL8817317 | 0.89 | SGMS2 (0.48) | SGMS2ALDH1A1MEN1KMT2APTGER1 | |
| SCHEMBL7975980 | 0.89 | SGMS2 (0.48) | SGMS2ALDH1A1MEN1KMT2APTGER1 | |
| SCHEMBL7975883 | 0.84 | POLB (0.47) | ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7990821 | 0.82 | TDP1 (0.47) | SGMS2ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL7975824 | 0.79 | SGMS2 (0.52) | SGMS2ALDH1A1MEN1KMT2APTGER1 | |
| SCHEMBL7987708 | 0.79 | SGMS2 (0.52) | SGMS2ALDH1A1MEN1KMT2APTGER1 | |
| SCHEMBL7990641 | 0.79 | SGMS2 (0.52) | SGMS2ALDH1A1MEN1KMT2APTGER1 | |
| SCHEMBL7975993 | 0.76 | ERAP1 (0.53) | — | |
| SCHEMBL7250367 | 0.76 | HTR1A (0.54) | SGMS2ALDH1A1MEN1KMT2APTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |