Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976048 | 1.00 | HTR2A (0.41) | HTR2AHTR2CHTR2BABCB1HTT | |
| SCHEMBL7976044 | 1.00 | HTR2A (0.41) | HTR2AHTR2CHTR2BABCB1HTT | |
| SCHEMBL11139872 | 0.79 | HTT (0.42) | HTR2AHTR2CHTR2BABCB1HTT | |
| SCHEMBL7971053 | 0.79 | HTT (0.39) | HTR2AHTR2CHTR2BABCB1HTT | |
| SCHEMBL7971050 | 0.79 | HTT (0.39) | HTR2AHTR2CHTR2BABCB1HTT | |
| SCHEMBL7971060 | 0.79 | HTT (0.39) | HTR2AHTR2CHTR2BABCB1HTT | |
| SCHEMBL25166311 | 0.78 | SLC9A1 (0.38) | SLC9A1TRPM4TRPM5 | |
| SCHEMBL9381070 | 0.75 | HTR2A (0.66) | HTR2AHTR2CHTR2BABCB1MEN1 | |
| SCHEMBL9381065 | 0.75 | HTR2A (0.66) | HTR2AHTR2CHTR2BABCB1MEN1 | |
| SCHEMBL7438967 | 0.75 | HTR2A (0.41) | HTR2AHTR2CHTR2BABCB1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |