Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 9/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976694 | 1.00 | CYP19A1 (0.41) | CYP19A1CYP11B1CYP11B2PTAFRSCN9A | |
| SCHEMBL8019943 | 1.00 | CYP19A1 (0.41) | CYP19A1CYP11B1CYP11B2PTAFRSCN9A | |
| SCHEMBL7966320 | 0.88 | CYP11B1 (0.40) | CYP19A1CYP11B1CYP11B2PTAFRSCN9A | |
| SCHEMBL7966319 | 0.88 | CYP11B1 (0.40) | CYP19A1CYP11B1CYP11B2PTAFRSCN9A | |
| SCHEMBL7978652 | 0.87 | CYP11B2 (0.43) | CYP19A1CYP11B1CYP11B2PTAFR | |
| SCHEMBL7978653 | 0.87 | CYP11B2 (0.43) | CYP19A1CYP11B1CYP11B2PTAFR | |
| SCHEMBL7822506 | 0.84 | CYP11B2 (0.38) | CYP19A1CYP11B1CYP11B2PTAFRHPGD | |
| SCHEMBL7822509 | 0.84 | CYP11B2 (0.38) | CYP19A1CYP11B1CYP11B2PTAFRHPGD | |
| SCHEMBL7980395 | 0.84 | MMP12 (0.47) | CYP19A1CYP11B1CYP11B2PTAFRKDM4E | |
| SCHEMBL7980127 | 0.84 | MMP12 (0.47) | CYP19A1CYP11B1CYP11B2PTAFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |