Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.75 |
| ▸ | FLT1 | P17948 | 4/20 | 0.75 |
| ▸ | FLT4 | P35916 | 4/20 | 0.75 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986720 | 0.88 | KDR (0.59) | KDRFLT1FLT4CYP3A4PRKACA | |
| SCHEMBL7547755 | 0.86 | KDR (1.00) | KDRFLT1FLT4CYP2A6PRKACA | |
| SCHEMBL7551380 | 0.85 | KDR (0.54) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7555413 | 0.83 | KDR (0.52) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7549028 | 0.83 | KDR (0.52) | KDRFLT1FLT4MAOBCYP3A4 | |
| SCHEMBL7508695 | 0.83 | KDR (0.74) | KDRFLT1FLT4CYP2A6MAOB | |
| SCHEMBL7987137 | 0.83 | KDR (0.74) | KDRFLT1FLT4CYP2A6PRKACA | |
| SCHEMBL7547036 | 0.82 | FLT1 (0.51) | KDRFLT1FLT4MAOBCYP3A4 | |
| SCHEMBL7988018 | 0.80 | KDR (0.78) | KDRFLT1FLT4CYP2A6PRKACA | |
| SCHEMBL7976429 | 0.80 | KDR (0.78) | KDRFLT1FLT4CYP2A6PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |