Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.54 |
| ▸ | F9 | P00740 | 2/20 | 0.54 |
| ▸ | F11 | P03951 | 2/20 | 0.54 |
| ▸ | F7 | P08709 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972817 | 0.90 | F9 (0.54) | F10F9F11F7CHEK2 | |
| SCHEMBL7960699 | 0.88 | F10 (0.67) | F10F9F11F7CHEK2 | |
| SCHEMBL1842124 | 0.83 | CHEK2 (0.61) | F10F9F11CHEK2CSNK1D | |
| SCHEMBL10029168 | 0.83 | CHEK2 (0.61) | F10F9F11CHEK2CSNK1D | |
| SCHEMBL10172686 | 0.81 | CHEK2 (0.69) | F10F9F11F7CHEK2 | |
| SCHEMBL20307797 | 0.80 | F9 (0.47) | F10F9F11F7CHEK2 | |
| SCHEMBL20307796 | 0.78 | F9 (0.44) | F10F9F11F7CHEK2 | |
| SCHEMBL20307818 | 0.78 | SIRT2 (0.46) | F10F9F11F7CHEK2 | |
| SCHEMBL7969187 | 0.77 | F10 (0.67) | F10F9F11F7F2 | |
| SCHEMBL20307774 | 0.77 | F10 (0.67) | F10F9F11F7CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |