Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.67 |
| ▸ | F9 | P00740 | 4/20 | 0.67 |
| ▸ | F11 | P03951 | 3/20 | 0.67 |
| ▸ | F7 | P08709 | 3/20 | 0.67 |
| ▸ | F2 | P00734 | 8/20 | 0.47 |
| ▸ | PLAU | P00749 | 8/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.47 |
| ▸ | PLG | P00747 | 7/20 | 0.47 |
| ▸ | PLAT | P00750 | 7/20 | 0.47 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20307774 | 0.89 | F10 (0.67) | F10F9F11F7F2 | |
| SCHEMBL7960699 | 0.89 | F10 (0.67) | F10F9F11F7F2 | |
| SCHEMBL7973134 | 0.87 | F10 (0.64) | F10F9F11F7F2 | |
| SCHEMBL7973887 | 0.81 | F10 (0.70) | F10F9F11F7F2 | |
| SCHEMBL7973776 | 0.81 | F10 (1.00) | F10F9F11F7F2 | |
| SCHEMBL7959410 | 0.80 | F10 (0.79) | F10F9F11F7F2 | |
| SCHEMBL10140709 | 0.79 | F10 (0.48) | F10F9F11F7F2 | |
| SCHEMBL7972817 | 0.77 | F9 (0.54) | F10F9F11F7 | |
| SCHEMBL7976836 | 0.77 | F10 (0.54) | F10F9F11F7F2 | |
| SCHEMBL7978435 | 0.77 | F10 (0.83) | F10F9F11F7F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |