Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.63 |
| ▸ | GAK | O14976 | 3/20 | 0.57 |
| ▸ | FBP1 | P09467 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.53 |
| ▸ | BUB1 | O43683 | 2/20 | 0.53 |
| ▸ | STK10 | O94804 | 2/20 | 0.53 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.53 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.53 |
| ▸ | CARS1 | P49589 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976867 | 0.86 | EGFR (0.70) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL7980380 | 0.83 | EGFR (0.65) | EGFRERBB2FBP1MAPTABCG2 | |
| SCHEMBL8548481 | 0.83 | EGFR (0.60) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL7982859 | 0.82 | EGFR (0.68) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL7978774 | 0.82 | EGFR (0.71) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL7966785 | 0.82 | CYP1A2 (0.72) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL183355 | 0.81 | ABCG2 (0.76) | EGFRERBB2GAKFBP1ALDH1A1 | |
| SCHEMBL29894409 | 0.81 | ABCG2 (0.76) | EGFRERBB2GAKFBP1ALDH1A1 | |
| SCHEMBL4351949 | 0.81 | EGFR (0.58) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL7982823 | 0.80 | EGFR (0.68) | EGFRERBB2ERBB4GAKFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | claimed |
| JP-10152477-A | — | — | None | — | — | JP | disclosed |
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| JP-H10152477-A | AMINOQUINAZOLINE DERIVATIVE | PFIZER INC | 1998-06-09 | — | — | JP | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |