Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5724638 | 0.81 | HTR2A (0.35) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5725539 | 0.79 | HTR2C (0.47) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL5725534 | 0.79 | HTR2C (0.47) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL5724839 | 0.79 | CHRM3 (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL5725074 | 0.79 | CHRM3 (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL5726347 | 0.79 | CHRM2 (0.32) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5726344 | 0.79 | CHRM2 (0.32) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| Bromide SCHEMBL5726761 | 0.79 | LMNA (0.44) | KDM4EKMT2ALMNAALDH1A1NPC1 | |
| Bromide SCHEMBL5726756 | 0.79 | LMNA (0.44) | KDM4EKMT2ALMNAALDH1A1NPC1 | |
| SCHEMBL5725224 | 0.78 | CHRM2 (0.32) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174909-B1 | FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE | H. LUNDBECK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| US-5998613-A | PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 1999-12-07 | — | — | US | disclosed |