SCHEMBL5726344

SCHEMBL5726344

CCOc1noc2c1C(NCCCC(c1ccccc1C)c1ccccc1C)CCC2

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32
CHRM1 P11229 1/20 0.32
CHRM3 P20309 1/20 0.32
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
LMNA P02545 1/20 0.32
CYP3A4 P08684 1/20 0.32
GAA P10253 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPC1 O15118 1/20 0.31
KDM4E B2RXH2 1/20 0.30
DHODH Q02127 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5726347 1.00 CHRM2 (0.32) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL5725224 0.97 CHRM2 (0.32) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL5724638 0.89 HTR2A (0.35) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL5725812 0.85 DHODH (0.35) MEN1KMT2ALMNAGAASMN1; SMN2
SCHEMBL5725809 0.85 DHODH (0.35) MEN1KMT2ALMNAGAASMN1; SMN2
SCHEMBL7977242 0.83 SOS1 (0.37) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL5724914 0.83 SCN5A (0.35) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL5724732 0.83 DHODH (0.34) MEN1KMT2ALMNAGAASMN1; SMN2
SCHEMBL5725795 0.81 SLC6A1 (0.34) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL5725226 0.80 KDM4E (0.33) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0812318-B1 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS LUNDBECK & CO AS H (DK) 2006-02-08 EP disclosed
US-6174909-B1 FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE H. LUNDBECK A/S (DK) 2001-01-16 US disclosed
US-5998613-A PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS H. LUNDBECK A/S (DK) 1999-12-07 US disclosed