Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.53 |
| ▸ | KLK1 | P06870 | 1/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915446 | 0.88 | POLB (0.63) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL305355 | 0.86 | POLB (0.64) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL12851299 | 0.84 | HTT (0.74) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL1386414 | 0.83 | LMNA (0.62) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL1386409 | 0.83 | LMNA (0.62) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL7080320 | 0.82 | MAPT (0.73) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL8288446 | 0.82 | LMNA (0.60) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL6908821 | 0.82 | SMN1; SMN2 (0.63) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL12201106 | 0.82 | SMN1; SMN2 (0.75) | POLBRAB9ASMN1; SMN2TSHRMAPK10 | |
| SCHEMBL10310221 | 0.81 | KLK1 (0.63) | POLBRAB9ASMN1; SMN2TSHRMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |