SCHEMBL7977763

SCHEMBL7977763

Cc1ccc(-c2[nH]c(-c3ccc4ccccc4c3)nc2C(=O)O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTRC Q99895 1/20 0.53
ALDH1A1 P00352 4/20 0.53
HPGD P15428 4/20 0.53
KDM4E B2RXH2 3/20 0.53
GLA P06280 2/20 0.53
GAA P10253 2/20 0.53
KMT2A Q03164 2/20 0.53
MEN1 O00255 1/20 0.53
PIN1 Q13526 7/20 0.51
MAPK14 Q16539 1/20 0.49
CHEK2 O96017 1/20 0.46
CYP1A2 P05177 2/20 0.44
MAPK1 P28482 1/20 0.44
CASP1 P29466 1/20 0.44
CYP2C19 P33261 1/20 0.44
DHODH Q02127 2/20 0.44
PKM P14618 1/20 0.43
CA12 O43570 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7978027 0.88 KDM4E (0.67) ALDH1A1HPGDKDM4EGLAGAA
SCHEMBL7995926 0.84 KDM4E (0.49) CTRCALDH1A1HPGDKDM4EGLA
SCHEMBL7977957 0.84 TOP2A (0.51) CTRCALDH1A1HPGDKDM4EGLA
SCHEMBL7977738 0.80 MAPK14 (0.56) ALDH1A1HPGDKDM4EGLAGAA
SCHEMBL7992039 0.80 MAPK14 (0.56) ALDH1A1HPGDKDM4EGLAGAA
SCHEMBL7991805 0.80 KDM4E (0.48) ALDH1A1HPGDKDM4EGLAGAA
SCHEMBL7989975 0.78 DHODH (0.61) ALDH1A1HPGDKDM4EGLAGAA
SCHEMBL29093221 0.78 PIN1 (0.69) ALDH1A1HPGDKDM4EGLAGAA
SCHEMBL7977705 0.78 DHODH (0.54) ALDH1A1HPGDKDM4EGLAGAA
SCHEMBL7977884 0.77 SIRT2 (0.56) ALDH1A1GAAKMT2AMEN1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288061-B1 INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS WELFIDE CORPORATION (JP) 2001-09-11 US disclosed