SCHEMBL7977813

SCHEMBL7977813

O=C(CCCNC(=O)c1ccc(Cl)cc1F)Oc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 1/20 0.40
ATM Q13315 1/20 0.37
KMT2A Q03164 3/20 0.37
POLB P06746 2/20 0.36
THRB P10828 1/20 0.35
RECQL P46063 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
GCG P01275 3/20 0.35
HDAC3 O15379 1/20 0.35
HDAC1 Q13547 1/20 0.35
NPC1 O15118 1/20 0.35
CDK1 P06493 1/20 0.34
ALDH1A1 P00352 2/20 0.34
MEN1 O00255 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA3 P07451 1/20 0.34
CA4 P22748 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7977673 0.90 KMT2A (0.45) KMT2APOLBTHRBRECQLTDP1
SCHEMBL7979244 0.89 GAA (0.38) HDAC1MAPT
SCHEMBL7965905 0.89 FOLH1 (0.40) FOLH1ATMKMT2APOLBTHRB
SCHEMBL7977810 0.85 NPSR1 (0.34) KMT2APOLBTDP1L3MBTL1NPC1
SCHEMBL7975945 0.82 POLB (0.38) FOLH1KMT2APOLBTHRBRECQL
SCHEMBL7979400 0.82 FLT1 (0.37) KMT2AHDAC1ALDH1A1MEN1MAPT
SCHEMBL7976381 0.82 HDAC1 (0.42) HDAC1CA12CA1CA2CA3
SCHEMBL7977672 0.80 TDP1 (0.38) KMT2APOLBTDP1L3MBTL1HDAC1
SCHEMBL8062554 0.79 KMT2A (0.48) ATMKMT2APOLBTHRBRECQL
SCHEMBL7965923 0.79 MAPT (0.46) KMT2APOLBTHRBTDP1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6214835-B1 CONTROLLING INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US disclosed
EP-0824514-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-09-06 EP disclosed
US-6028100-A Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-02-22 US disclosed
US-5952386-A EXCELLENT INSECTICIDAL ACTIVITY FOR THE CONTROL OF NOXIOUS INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-09-14 US disclosed
EP-0824514-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1998-02-25 EP disclosed
WO-1996033160-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-10-24 WO disclosed