SCHEMBL7979400

SCHEMBL7979400

O=C(CCCNC(=O)c1ccc(C(F)(F)F)cc1C(F)(F)F)Oc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 1/20 0.37
FLT4 P35916 1/20 0.37
KDR P35968 1/20 0.37
RHOC P08134 2/20 0.36
RHOA P61586 2/20 0.36
ESRRG P62508 1/20 0.35
MRGPRX4 Q96LA9 4/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
CES2 O00748 1/20 0.34
PPARD Q03181 2/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
KMT2A Q03164 2/20 0.33
PPARG P37231 1/20 0.33
PPARA Q07869 1/20 0.33
GSK3B P49841 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7979244 0.91 GAA (0.38) RHOCRHOAMRGPRX4GAAMAPT
SCHEMBL7976381 0.91 HDAC1 (0.42) RHOCRHOAMRGPRX4GAAMAPT
SCHEMBL7965747 0.89 RHOC (0.42) FLT1FLT4KDRRHOCRHOA
SCHEMBL7965923 0.88 MAPT (0.46) FLT1FLT4KDRGAAMAPT
SCHEMBL7979399 0.86 MAPT (0.34) GAAMAPTHTTHDAC1KMT2A
SCHEMBL7979434 0.82 RHOC (0.39) FLT1FLT4KDRRHOCRHOA
SCHEMBL7977813 0.82 FOLH1 (0.40) MAPTHDAC1KMT2AMEN1ALDH1A1
SCHEMBL7976379 0.82 HDAC1 (0.39) MAPTHDAC1KMT2AMEN1ALDH1A1
SCHEMBL7977673 0.81 KMT2A (0.45) MAPTHTTKMT2AMEN1ALDH1A1
SCHEMBL7979241 0.81 MAPT (0.37) KDRGAAMAPTHTTHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6214835-B1 CONTROLLING INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US disclosed
EP-0824514-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-09-06 EP disclosed
US-6028100-A Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-02-22 US disclosed
US-5952386-A EXCELLENT INSECTICIDAL ACTIVITY FOR THE CONTROL OF NOXIOUS INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-09-14 US disclosed
WO-1996033160-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-10-24 WO disclosed