Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | NAMPT | P43490 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978001 | 1.00 | LATS1 (0.37) | LATS1HRH4CYP3A4NAMPTCYP2C9 | |
| SCHEMBL8195513 | 0.82 | NAMPT (0.53) | HRH4CYP3A4NAMPTCYP2C9CYP2C19 | |
| SCHEMBL8195515 | 0.82 | NAMPT (0.53) | HRH4CYP3A4NAMPTCYP2C9CYP2C19 | |
| SCHEMBL7098788 | 0.82 | HRH4 (0.43) | HRH4CYP3A4NAMPTCYP2C9CYP2C19 | |
| SCHEMBL8196333 | 0.81 | ADRB2 (0.36) | HRH4NAMPTLMNAIMPDH2 | |
| SCHEMBL8196331 | 0.81 | ADRB2 (0.36) | HRH4NAMPTLMNAIMPDH2 | |
| SCHEMBL8200604 | 0.81 | NAMPT (0.35) | HRH4NAMPTLMNAQPCTIMPDH2 | |
| SCHEMBL8195619 | 0.80 | MEN1 (0.44) | CYP3A4NAMPTCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL8195623 | 0.80 | MEN1 (0.44) | CYP3A4NAMPTCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL8919392 | 0.80 | HRH4 (0.48) | HRH4CYP3A4NAMPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255323-B1 | Cyanoguanidine compounds | SHIONOGI BIORESEARCH CORP. | 2001-07-03 | — | — | US | disclosed |
| WO-2000061561-A1 | CYANOGUANIDINE COMPOUNDS | SHIONOGI BIORESEARCH CORP. (US) | 2000-10-19 | — | — | WO | disclosed |