Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978276 | 0.82 | HRH4 (0.49) | HTR2CHTR1A | |
| SCHEMBL7996524 | 0.80 | HTR2C (0.49) | HTR2CDRD2HTR2ADRD3 | |
| SCHEMBL7989669 | 0.77 | KCNH2 (0.35) | — | |
| SCHEMBL5386406 | 0.76 | HSD17B10 (0.45) | — | |
| SCHEMBL7447432 | 0.75 | HSD17B10 (0.47) | — | |
| SCHEMBL7978522 | 0.74 | — | — | |
| SCHEMBL5381026 | 0.73 | AR (0.44) | — | |
| SCHEMBL7978699 | 0.73 | MAPT (0.52) | — | |
| SCHEMBL3681749 | 0.69 | HTR2C (0.70) | HTR2CABCB1ABCC1ABCG2DRD2 | |
| SCHEMBL7989788 | 0.69 | ALDH1A1 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001070728-A1 | 2-[NITROGEN-HETEROCYCLIC]PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | claimed |
| WO-2001070728-A1 | 2-[NITROGEN-HETEROCYCLIC]PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | disclosed |