Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968459 | 0.87 | NPY5R (0.54) | KMT2ANPY5RKDM4ENPC1ALDH1A1 | |
| SCHEMBL7979823 | 0.85 | POLB (0.43) | NPY5RROCK2ROCK1NPC1RAB9A | |
| SCHEMBL10666737 | 0.79 | NPY5R (0.50) | KMT2ANPY5RROCK2ROCK1CDC42BPB | |
| SCHEMBL7982268 | 0.79 | NPY5R (0.44) | KMT2ANPY5RKDM4EALDH1A1MAPT | |
| SCHEMBL7981498 | 0.78 | CBFB (0.45) | NPY5RROCK2ROCK1CDC42BPBKDM4E | |
| SCHEMBL10669976 | 0.75 | LRRK2 (0.49) | KMT2ANPY5RROCK2ROCK1CDC42BPB | |
| SCHEMBL7981521 | 0.75 | NCF1 (0.36) | KMT2ANPY5RROCK2ROCK1CDC42BPB | |
| SCHEMBL7978430 | 0.73 | METAP1 (0.36) | NPY5RNCF1 | |
| SCHEMBL5416659 | 0.71 | NCF1 (0.56) | KMT2ANPY5RROCK1KDM4EALDH1A1 | |
| SCHEMBL5412427 | 0.71 | NCF1 (0.59) | KMT2ANPY5RROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003744-A1 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1999007703-A1 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 1999-02-18 | — | — | WO | claimed |
| US-6187778-B1 | EATING AND CARDIOVASCULAR DISORDERS | PFIZER INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1003744-A1 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007703-A1 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 1999-02-18 | — | — | WO | disclosed |