Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 8/20 | 0.45 |
| ▸ | METAP1 | P53582 | 4/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 4/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968459 | 0.83 | NPY5R (0.54) | NPY5RKDM4ENCF1NPC1RAB9A | |
| SCHEMBL7979823 | 0.79 | POLB (0.43) | NPY5RNCF1ROCK2ROCK1NPC1 | |
| SCHEMBL7978430 | 0.79 | METAP1 (0.36) | METAP1NPY5RNCF1 | |
| SCHEMBL7981521 | 0.78 | NCF1 (0.36) | NPY5RKDM4ENCF1ROCK2ROCK1 | |
| SCHEMBL7978337 | 0.78 | KMT2A (0.50) | NPY5RKDM4ENCF1ROCK2ROCK1 | |
| SCHEMBL124273 | 0.74 | CBFB (0.68) | CBFBMETAP1KDM4EMETAP2NPC1 | |
| SCHEMBL12944360 | 0.69 | NPC1 (0.56) | CBFBMETAP1KDM4EMETAP2NPC1 | |
| SCHEMBL7968456 | 0.68 | NCF1 (0.41) | NPY5RKDM4ENCF1NPC1RAB9A | |
| SCHEMBL125111 | 0.67 | CBFB (0.67) | CBFBMETAP1KDM4EMETAP2NPC1 | |
| SCHEMBL14895434 | 0.66 | MTOR (0.69) | CBFBMETAP1KDM4EMETAP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003744-A1 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1999007703-A1 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 1999-02-18 | — | — | WO | claimed |
| US-6187778-B1 | EATING AND CARDIOVASCULAR DISORDERS | PFIZER INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1003744-A1 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007703-A1 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 1999-02-18 | — | — | WO | disclosed |