Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 11/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646851 | 0.86 | GABRA1 (0.46) | KDM4EALDH1A1HTTLMNAHSD17B10 | |
| SCHEMBL6768851 | 0.76 | HSD11B1 (0.40) | SMN1; SMN2HTTLMNALRRK2POLB | |
| SCHEMBL7962331 | 0.76 | GABRA1 (0.50) | BCHERXFP1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7972521 | 0.74 | BCHE (0.42) | BCHERXFP1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7972253 | 0.74 | GABRG2 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7978467 | 0.73 | MEN1 (0.50) | BCHERXFP1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2646928 | 0.72 | GABRA1 (0.52) | KDM4EALDH1A1HTTLMNAHSD17B10 | |
| SCHEMBL2646413 | 0.72 | GABRA1 (0.50) | BCHEKDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6996163 | 0.71 | BRD4 (0.51) | KDM4EHTTLMNAHSD17B10LRRK2 | |
| SCHEMBL7984270 | 0.70 | BCHE (0.39) | BCHERXFP1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291460-B1 | TREATMENT OF ANXIETY; TREATMENT AND/OR PREVENTION OF CONVULSIONS | MERCK SHARP & DOHME LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |
| EP-1056748-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999037647-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |