Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13779370 | 0.97 | KMT2A (0.38) | APEX1NPSR1MEN1KMT2ANFKB1 | |
| SCHEMBL5550564 | 0.97 | KMT2A (0.38) | APEX1NPSR1MEN1KMT2ANFKB1 | |
| Bromide SCHEMBL5551175 | 0.95 | MEN1 (0.41) | APEX1NPSR1MEN1KMT2ANFKB1 | |
| Bromide SCHEMBL5550573 | 0.95 | MEN1 (0.41) | APEX1NPSR1MEN1KMT2ANFKB1 | |
| Bromide SCHEMBL27245942 | 0.92 | BBOX1 (0.38) | APEX1NPSR1MEN1KMT2ANFKB1 | |
| Hydrochloric Acid SCHEMBL139393 | 0.91 | DNM1 (0.50) | KMT2ATSHRDNM1HTTPLA2G1B | |
| Hydrochloric Acid SCHEMBL6697657 | 0.91 | DNM1 (0.50) | KMT2ATSHRDNM1HTTPLA2G1B | |
| Hydrochloric Acid SCHEMBL9820762 | 0.91 | DNM1 (0.50) | KMT2ATSHRDNM1HTTPLA2G1B | |
| Hydrochloric Acid SCHEMBL10871817 | 0.91 | DNM1 (0.50) | KMT2ATSHRDNM1HTTPLA2G1B | |
| Hydrochloric Acid SCHEMBL9123236 | 0.91 | DNM1 (0.50) | KMT2ATSHRDNM1HTTPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225445-A | ENHANCED OIL RECOVERY | CALGON CORPORATION (US) | 1980-09-30 | — | — | US | claimed |
| US-6271264-B1 | REMOVING BILE ACIDS FROM PATIENTS | GELTEX PHARMACEUTICALS, INC. | 2001-08-07 | — | — | US | disclosed |
| WO-2000032656-A2 | POLYMERS CONTAINING SPIROBICYCLIC AMMONIUM MOIETIES AND USE THEREOF | GELTEX PHARMACEUTICALS, INC. (US) | 2000-06-08 | — | — | WO | disclosed |
| US-4225445-A | ENHANCED OIL RECOVERY | CALGON CORPORATION (US) | 1980-09-30 | — | — | US | disclosed |