Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979148 | 0.94 | CARM1 (0.49) | CARM1DRD3DRD2HTR7PRMT5 | |
| SCHEMBL7744214 | 0.84 | DRD2 (0.64) | CARM1DRD3DRD2PRMT5L3MBTL1 | |
| SCHEMBL4229926 | 0.80 | HTR7 (0.64) | DRD3DRD2HTR7HDAC3HDAC1 | |
| SCHEMBL6975839 | 0.79 | ABCB1 (0.55) | ABCB1 | |
| SCHEMBL7844061 | 0.79 | DRD2 (0.74) | DRD3DRD2HTR7PRMT5HTR1A | |
| SCHEMBL6980960 | 0.79 | DRD3 (0.43) | DRD3DRD2HTR7ABCB1HTR1A | |
| Hydrochloric Acid SCHEMBL4224319 | 0.78 | HTR7 (0.62) | DRD3DRD2HTR7L3MBTL1HDAC3 | |
| SCHEMBL27921604 | 0.78 | HTR7 (0.62) | DRD3DRD2HTR7HDAC3HDAC1 | |
| SCHEMBL4225899 | 0.78 | HTR7 (0.62) | DRD3DRD2HTR7HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL4222983 | 0.78 | HTR7 (0.62) | DRD3DRD2HTR7L3MBTL1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143762-A | DRUGS AS DOPAMINE ANTAGONIST PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM, PLC (GB) | 2000-11-07 | — | — | US | disclosed |
| EP-0922035-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM PLC (GB) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006699-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM PLC (GB) | 1998-02-19 | — | — | WO | disclosed |