SCHEMBL7979494

SCHEMBL7979494

Cc1cc(C(C)(C)C)ccc1CO

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KLF10 Q13118 1/20 0.47
HTR1D P28221 2/20 0.46
HTR1B P28222 2/20 0.46
ADRA2A P08913 1/20 0.46
ADRA2B P18089 1/20 0.46
ADRA2C P18825 1/20 0.46
ADRA1D P25100 1/20 0.46
ADRA1A P35348 1/20 0.46
ADRA1B P35368 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C19 P33261 1/20 0.46
ALDH1A1 P00352 2/20 0.45
HPGD P15428 1/20 0.45
ALOX15 P16050 1/20 0.45
HSD17B10 Q99714 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
EPHX2 P34913 2/20 0.44
RXRA P19793 1/20 0.44
RXRB P28702 1/20 0.44
CYP2D6 P10635 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14525322 0.87 RXRB (0.53) KLF10HTR1DHTR1BADRA2AADRA2B
SCHEMBL10211670 0.85 KLF10 (0.50) KLF10HTR1DHTR1BADRA2AADRA2B
SCHEMBL22275799 0.84 KLF10 (0.53) KLF10HTR1DHTR1BADRA2AADRA2B
SCHEMBL15800261 0.83 HTR1D (0.44) KLF10HTR1DHTR1BADRA2AADRA2B
SCHEMBL1447610 0.83 KLF10 (0.47) KLF10HTR1DHTR1BADRA2AADRA2B
SCHEMBL5112247 0.81 DAO (0.46) KLF10RXRARXRBCYP2D6
SCHEMBL4508763 0.81 ALDH1A1 (0.59) KLF10CYP1A2CYP2C19ALDH1A1HPGD
SCHEMBL8849687 0.80 HTR1D (0.42) KLF10HTR1DHTR1BADRA2AADRA2B
SCHEMBL18901113 0.79 ALDH1A1 (0.57) KLF10HTR1DCYP1A2CYP2C19ALDH1A1
SCHEMBL4066357 0.79 CYP2C19 (0.46) KLF10CYP1A2CYP2C19ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288101-B1 ADMINISTERING COMPOUNDS SUCH AS 2,6-DIMETHYL-4-ISOPROPYLBENZALDEHYDE TO TREAT INDICATIONS WHERE STIMULATION OF SUBTYPES OF THE SEROTONIN RECEPTOR IS IMPLICATED, SUCH AS MIGRAINES VIRGINIA COMMONWEALTH UNIVERSITY 2001-09-11 US disclosed
US-6124338-A TREATING MIGRAINE HEADACHE VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-09-26 US disclosed
US-6048862-A Benzylamidine derivatives with serotonin receptor binding activity VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-04-11 US disclosed
US-5969137-A TREATMENT OF NERVOUS SYSTEM DISORDERS VIRGINIA COMMONWEALTH UNIVERSITY (US) 1999-10-19 US disclosed
WO-1998012183-A1 IMIDAZOLES WITH SEROTONIN RECEPTOR BINDING ACTIVITY ALLELIX BIOPHARMACEUTICALS INC. (CA) 1998-03-26 WO disclosed
US-4013640-A SOLVENT EXTRACTION, DISTILLATION UNION CARBIDE CORPORATION (US) 1977-03-22 US disclosed