Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.55 |
| ▸ | EDNRA | P25101 | 8/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | DHPS | P49366 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997031 | 0.92 | EDNRB (0.59) | EDNRBEDNRAIRAK4POLBPLK1 | |
| SCHEMBL7993871 | 0.92 | EDNRB (0.56) | EDNRBEDNRAIRAK4DHPS | |
| SCHEMBL7993551 | 0.84 | EDNRA (0.49) | EDNRBEDNRAIRAK4POLBDHPS | |
| SCHEMBL7997032 | 0.84 | EDNRB (0.59) | EDNRBEDNRADHPS | |
| SCHEMBL7996803 | 0.84 | EDNRA (0.48) | EDNRBEDNRAIRAK4POLBDHPS | |
| SCHEMBL7997029 | 0.83 | EDNRA (0.49) | EDNRBEDNRAIRAK4POLBPLK1 | |
| SCHEMBL7979535 | 0.82 | EDNRB (0.50) | EDNRBEDNRADHPSMAPT | |
| SCHEMBL7997001 | 0.81 | EDNRA (0.51) | EDNRBEDNRAIRAK4 | |
| SCHEMBL7993994 | 0.80 | EDNRB (0.56) | EDNRBEDNRADHPS | |
| SCHEMBL7993553 | 0.75 | DHPS (0.50) | EDNRBEDNRAIRAK4POLBDHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |