SCHEMBL7979676

SCHEMBL7979676

Cc1cc(C(C)(C)C)cc(C)c1Cc1nccn1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 6/20 0.47
ADRA2A P08913 2/20 0.47
ADRA2B P18089 2/20 0.47
ADRA2C P18825 2/20 0.47
HTR1B P28222 4/20 0.44
TSHR P16473 3/20 0.44
HTR1A P08908 2/20 0.44
LMNA P02545 2/20 0.44
OPRK1 P41145 2/20 0.44
TP53 P04637 1/20 0.44
CHRM2 P08172 1/20 0.44
CYP2D6 P10635 1/20 0.44
CHRM1 P11229 1/20 0.44
DRD2 P14416 1/20 0.44
CHRM3 P20309 1/20 0.44
ADRA1D P25100 1/20 0.44
HTR2A P28223 1/20 0.44
HTR2C P28335 1/20 0.44
MAPK1 P28482 1/20 0.44
ADRA1A P35348 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7970331 0.98 HTR1D (0.46) HTR1DADRA2AADRA2BADRA2CHTR1B
SCHEMBL7981115 0.75 HTR1D (0.52) HTR1DADRA2CHTR1BLMNAMEN1
SCHEMBL4063363 0.74 FDPS (0.48) TSHRLMNAOPRK1POLBMEN1
Hydrochloric Acid SCHEMBL7982787 0.74 HTR1D (0.51) HTR1DADRA2CHTR1BHTR1ALMNA
SCHEMBL7980794 0.71 HTR1D (0.39) HTR1DADRA2AADRA2BADRA2CHTR1B
SCHEMBL30834429 0.69 ALDH1A1 (0.52) TSHRLMNATP53CYP2D6MAPK1
SCHEMBL48663 0.68
SCHEMBL17713270 0.68 FDPS (0.53) TSHRLMNAOPRK1MAPTMEN1
SCHEMBL25482268 0.68 ADRA2C (0.48) ADRA2CLMNATP53CYP2D6CYP3A4
SCHEMBL4404604 0.67 FDPS (0.56) TSHRLMNAOPRK1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288101-B1 ADMINISTERING COMPOUNDS SUCH AS 2,6-DIMETHYL-4-ISOPROPYLBENZALDEHYDE TO TREAT INDICATIONS WHERE STIMULATION OF SUBTYPES OF THE SEROTONIN RECEPTOR IS IMPLICATED, SUCH AS MIGRAINES VIRGINIA COMMONWEALTH UNIVERSITY 2001-09-11 US claimed
US-6124338-A TREATING MIGRAINE HEADACHE VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-09-26 US claimed
WO-1998012183-A1 IMIDAZOLES WITH SEROTONIN RECEPTOR BINDING ACTIVITY ALLELIX BIOPHARMACEUTICALS INC. (CA) 1998-03-26 WO claimed
US-6288101-B1 ADMINISTERING COMPOUNDS SUCH AS 2,6-DIMETHYL-4-ISOPROPYLBENZALDEHYDE TO TREAT INDICATIONS WHERE STIMULATION OF SUBTYPES OF THE SEROTONIN RECEPTOR IS IMPLICATED, SUCH AS MIGRAINES VIRGINIA COMMONWEALTH UNIVERSITY 2001-09-11 US disclosed
US-6124338-A TREATING MIGRAINE HEADACHE VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-09-26 US disclosed
WO-1998012183-A1 IMIDAZOLES WITH SEROTONIN RECEPTOR BINDING ACTIVITY ALLELIX BIOPHARMACEUTICALS INC. (CA) 1998-03-26 WO disclosed